C. L. Lutcher, M.D.; L. A. Lindesmith, M.D.; F. S. Pettyjohn, M.D.; W. T. Steudel, M.D.; T. B. Dunkel, M.D.; J. A. Ionno; E. B. Cooper, M.D., F.A.C.P.
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Forty-seven culture-proven cases of meningococcemia and meningitis due to Neisseria meningitidis were recently diagnosed and treated at our institution. Emphasis was placed on the earliest possible detection and treatment of intravascular clotting (IVC). All patients were screened with the protamine test, as described by Kowalski, in addition to a coagulation battery which included prothrombin time, partial thromboplastin time, platelet count, fibrinogen, thrombin time, and antihemophilic globulin assay.
Thirteen patients had positive protamine tests on admission. Only five, however, had unquestioned IVC. Evidence for IVC in four other patients was equivocal. Four patients had positive protamine tests without further evidence of
Lutcher CL, Lindesmith LA, Pettyjohn FS, Steudel WT, Dunkel TB, Ionno JA, et al. Early Detection and Therapy of Intravascular Clotting During an Outbreak of Meningococcal Disease.. Ann Intern Med. ;72:797. doi: 10.7326/0003-4819-72-5-797_4
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Published: Ann Intern Med. 1970;72(5):797.
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