Joseph Post, M.D., F.A.C.P.; Joseph Hoffman, M.D., (Associate)
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Clinical experience has shown that the use of antimetabolites in the treatment of cancer and as immunosuppressants is limited by the tolerance of the host for the destruction of replicating hematopoietic and gut cells. Previous in vivo studies from this laboratory have correlated these effects with the more rapid multiplication of the normal populations vis-à-vis the coexistent autogenous tumor cells (New Eng J Med 279:248, 1968; National Cancer Institute Monograph No. 30, p. 209, 1969). This report deals with the effects of nitrogen mustard and methotrexate, administered at sublethal dose levels, upon the renewal patterns of coexistent ileal cells and
Post J, Hoffman J. Effects of Antimetabolites upon the Renewal Patterns of Normal Cells.. Ann Intern Med. ;72:798. doi: 10.7326/0003-4819-72-5-798_4
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Published: Ann Intern Med. 1970;72(5):798.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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