Henry T. Lynch, M.D.; Anne J. Krush, M.S.
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The cancer family syndrome is characterized by increased incidence of adenocarcinoma, primarily of the colon and endometrium; increased frequency of multiple primary malignant neoplasms (20% or more); early age of onset; and autosomal dominant inheritance. Investigation of this syndrome was carried out on seven large kindreds in order to determine its clinical manifestations, possible incidence in the population, and to demonstrate the practical application of genetic information as an aid to earlier cancer diagnosis. Medical genetic information was compiled by means of physicians' and hospital records, questionnaires, and field trips for personal examination of family members. In addition, gastroenterologists and
Lynch HT, Krush AJ. Recent Progress in Cancer Family Syndrome.. Ann Intern Med. ;72:800. doi: 10.7326/0003-4819-72-5-800_1
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Published: Ann Intern Med. 1970;72(5):800.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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