G. C. Bernhard, M.D., F.A.C.P.
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Azathioprine has been reported to be helpful in suppressing the renal destruction of systemic lupus erythematosus (SLE). Fourteen patients with SLE who had definite renal involvement were treated with 3 mg/kg body weight of azathioprine and the least dose of prednisone necessary to control extrarenal manifestations of the disease. Lupus nephritis was diagnosed from the urine sediment, quantitative proteinuria, and renal biopsy. The majority of patients had a repeat biopsy at the end of 6 to 12 months of therapy. Serum complement, beta10 complement, and antinuclear factor titers were followed serially as were renal function studies. Ten patients showed clinical
Bernhard GC. Evaluation of Azathioprine for the Treatment of Lupus Nephritis.. Ann Intern Med. ;72:802. doi: 10.7326/0003-4819-72-5-802_3
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Published: Ann Intern Med. 1970;72(5):802.
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