Guy Lacy Schless, M.D., (Associate)
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An arginine derivative, gamma-guanidinobutyramide (Augmentin®) was investigated with W. J. H. Butterfield of Guy's Hospital Medical School and Sir Charles Dodds, London. No significant hypoglycemic action was detected in 44 diabetics: in 3 who had uremia the blood urea became normal. Subsequently, 12 uremic diabetics were given 0.6 to 1.2 g of Augmentin daily for 10 to 14 days at Guy's Hospital and the Pennsylvania Hospital. Blood urea and blood urea nitrogen (BUN) values, especially below 100 and 50 mg/100 ml, fell toward normal, the greatest fall being 52 and 45 mg/100 ml, respectively. Elevated uric acid levels were lowered
Schless GL. A Drug That Lowers Blood Urea in Uremic Diabetics.. Ann Intern Med. ;72:803–804. doi: 10.7326/0003-4819-72-5-803_5
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Published: Ann Intern Med. 1970;72(5):803-804.
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