Neal J. Weinreb, M.D.; Rosamond Janis, M.D.; K. P. Eshwar, M.D.; Edward Weinstein, M.D.; Richard Hays, M.D.
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The Fanconi syndrome in adults is generally associated with multiple myeloma, amyloidosis, hyperglobulinemia, and nephrotoxic metals and drugs. This report described a generalized defect in proximal tubular function in a nephrotic patient with membranous glomerulonephritis. A 65-year-old man was admitted with an 8-year history of mild proteinuria and a 3-month history of edema progressing to anasarca. He had heavy proteinuria (8 to 9 g/day), hypoalbuminemia (1.2 g/100 ml), and renal insufficiency (creatinine clearance, 16 ml/min). In addition, he was found to have renal glycosuria (urine glucose, 6 g/liter with serum glucose 95 and 100 mg/100 ml) and aminoaciduria, with significantly
Weinreb NJ, Janis R, Eshwar KP, Weinstein E, Hays R. Renal Glycosuria, Aminoaciduria, and Proximal Renal Tubular Acidosis in Association with Membranous Glomerulonephritis.. Ann Intern Med. ;72:805. doi: 10.7326/0003-4819-72-5-805_3
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Published: Ann Intern Med. 1970;72(5):805.
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