Daniel E. Leb, M.D., F.A.C.P.; Bob S. Kanovitz, M.D.; Bernard Weisskopf, M.D.
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To date only five successful pregnancies in renal allograft recipients have been reported. Data on the adverse effects of azathioprine and prednisone on the fetus in the allograft situation is sketchy.
Eighteen months before delivery, this 26-year-old white woman received a cadaver kidney transplant after being on hemodialysis. The patient was found to have an entirely normal response to pregnancy. Renal clearance of creatinine increased as would be expected. Late in pregnancy edema, hypertension, and proteinuria developed, suggesting that preeclampsia could occur in the allograft.
Immunosuppression continued throughout pregnancy. Azathioprine dosage was reduced from 150 mg/day to 100 mg/day and
Daniel E. Leb, Bob S. Kanovitz, Bernard Weisskopf. Chromosomal Abnormalities in the Offspring of a Renal Transplant Recipient.. Ann Intern Med. 1970;72:805–806. doi: 10.7326/0003-4819-72-5-805_4
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Published: Ann Intern Med. 1970;72(5):805-806.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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