J. C. de la Torre, Ph.D.
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The possibility that dimethyl sulfoxide (DMSO) may facilitate the transport of other drug molecules across the blood-brain barrier (bbb) was studied using 3, 4-dihydroxyphenylalanine (L-DOPA) and 5-hydroxytryptophan (5-HTP). These two amino acids are the direct precursors of dopamine and serotonin respectively.
Male Sprague-Dawley rats were injected with a solution containing 75 mg/kg of L-DOPA and 750 mg/kg of DMSO. A second group of animals were injected with a similar solution containing 100 mg/kg of 5-HTP and 750 mg/kg of DMSO. Control animals received the same doses of L-DOPA and 5-HTP preceded by the dopa decarboxylase inhibitor (DCI) Ro 4-4602. All
J. C. de la Torre. The Blood-Brain Barrier for Monoamine Precursors After DMSO.. Ann Intern Med. 1970;72:806. doi: 10.7326/0003-4819-72-5-806_3
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Published: Ann Intern Med. 1970;72(5):806.
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