Stanley Platman, M.D.
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Lithium has now become an accepted therapy in the treatment and prevention of manic episodes. The empirical basis for its mechanism of action is considered to be related to alterations in the level of intracellular sodium.
Based on a reduced intracellular potassium in depression, rubidium has been found to act as a potential modifier of affect and behavior.
Lithium prevents the binding of sodium and potassium by strandin in neuronal membranes in vivo, whereas rubidium has an effect, in a sense, "opposite" to the effect of lithium in vitro on strandin constrained in an artificial "membrand." Forty ml (80 mEq)
Platman S. The Role of Cations in Psychiatry.. Ann Intern Med. 1970;72:807–808. doi: 10.7326/0003-4819-72-5-807_6
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Published: Ann Intern Med. 1970;72(5):807-808.
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