Albert L. Hyman, M.D., F.A.C.P.
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Although lidocaine, and ganglionic and adrenergic blockers are widely used in dire cardiopulmonary illness, the direct effects of these agents on pulmonary vasculature tone are poorly understood. Direct effects were obscured in previous studies by indirect effects resulting from simultaneous cardiac and peripheral actions of these agents. Both effects were studied simultaneously in intact dogs by catheter technics designed to perfuse a hemodynamically separated lobe at constant flows. A 20 F balloon catheter was passed into a lobar pulmonary artery, the balloon was distended, and the hemodynamically separated lobe was pump-perfused with aortic blood. Intrathoracic vascular pressures were obtained with
Hyman AL. Pulmonary Vascular Effects of Lidocaine and Ganglionic and Adrenergic Blockers.. Ann Intern Med. ;72:809–810. doi: 10.7326/0003-4819-72-5-809_5
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Published: Ann Intern Med. 1970;72(5):809-810.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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