Joseph L. Grant, M.D., F.A.C.P.; Eugene Lussier, M.D.; Mark Mahnke
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Respiratory-center drive may be lessened in patients with chronic obstructive pulmonary disease. This study reports on the assessment of respiratory-center drive by having patients breathe mixtures of carbon dioxide in increasing concentration with and without helium. With turbulent air flow, helium offers a decrease in airway resistance, and if ventilation rises normally when helium replaces nitrogen in the inspired gas, one can conclude that respiratory-center sensitivity to carbon dioxide is intact. The results in 27 normal subjects, 14 patients with chronic obstructive disease, and 1 patient with idiopathic hypoventilation are presented in support of this concept. They breathed 0, 3,
Joseph L. Grant, Eugene Lussier, Mark Mahnke. Estimation of Respiratory Center Drive With Carbon-Dioxide-Helium.. Ann Intern Med. 1970;72:810. doi: 10.7326/0003-4819-72-5-810_2
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Published: Ann Intern Med. 1970;72(5):810.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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