BRENDAN P. TEEHAN, M.D.; JOHN F. MAHER, M.D., F.A.C.P.; JAMES J. H. CAREY, M.D.; PAULINE D. FLYNN, B.S.; GEORGE E. SCHREINER, M.D., F.A.C.P.
Experience with six consecutive patients with severe acute ethchlorvynol (Placidyl®) intoxication is described, and the pertinent literature is reviewed. The typical clinical picture consisted of prolonged deep coma, hypothermia, marked respiratory depression, hypotension that usually responded to conventional therapy, and relative bradycardia despite significant hypotension. Complications included severe infections, cardiorespiratory arrest, peripheral neuropathy, and pulmonary edema. Serum levels were as high as 16.6 mg/100 ml, and the distribution space exceeded total body water. Clearances by peritoneal dialysis, forced diuresis, and hemodialysis were 18.5, 23, and 64 ml/ min, respectively. Hourly removal rates ranged from 85 to 210 mg/hr by forced diuresis and 175 to 344 mg/hr by hemodialysis. The serum half-life was shortened from over 70 hr to 22 hr when hemodialysis was used.
TEEHAN BP, MAHER JF, CAREY JJH, FLYNN PD, SCHREINER GE. Acute Ethchlorvynol (Placidyl®) Intoxication. Ann Intern Med. ;72:875–882. doi: 10.7326/0003-4819-72-6-875
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Published: Ann Intern Med. 1970;72(6):875-882.
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