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The existence of a central homeostatic system that regulates the normal growth of tissues throughout the body and which deteriorates in a highly specific manner to promote a broad variety of diseases and conditions of aging is a concept of substantial appeal. Based on the respective, seminal conclusions of Burnet and Burwell that autoimmune diseases could result from a central breakdown in self-tolerance and that the growth of mammals is centrally regulated by the lymphoid system, Burch concludes in this book that the normal function of mesenchymal stem cells is the regulation of growth.
In an attempt to characterize the
An Inquiry Concerning Growth, Disease and Aging.. Ann Intern Med. ;72:974–975. doi: 10.7326/0003-4819-72-6-974_2
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Published: Ann Intern Med. 1970;72(6):974-975.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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