ARTHUR F. WHEREAT, M.D., F.A.C.P.
Recent interest in the relationship of carbon monoxide to the development of coronary artery disease has implicated disturbances of cellular respiration in the pathogenesis of atherosclerosis. The arterial wall is an active participant in the atherosclerotic process. Arterial fatty acid synthesis takes place in the mitochondria and is regulated by the reduced nicotinamide-adenine dinucleotide to nicotinamide-adenine dinucleotide (NADH/NAD+) ratio. Carbon monoxide and other respiratory inhibitors in our environment cause an abrupt increase in the mitochondrial NADH/NAD+ and consequently greatly stimulate lipid synthesis within the artery. It is suggested that this is the pathogenetic sequence by which carbon monoxide causes increased lipid synthesis and lesion development in the artery.
WHEREAT AF. Is Atherosclerosis a Disorder of Intramitochondrial Respiration?. Ann Intern Med. ;73:125–127. doi: 10.7326/0003-4819-73-1-125
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Published: Ann Intern Med. 1970;73(1):125-127.
Cardiology, Coronary Heart Disease.
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