RUSSELL E. RANDALL JR., M.D., F.A.C.P.; GEORGE S. BRIDI, M.D.; JOHN G. SETTER, M.D.; NEWTON C. BRACKETT JR., M.D.
To the editor: Renal failure due to sodium colistimethate has usually been mild and transient (1), although more severe cases have occurred, generally with a fatal outcome (2, 3). We would like to record our observations in a 41-year-old man who developed severe oliguric renal failure after an excessive dose of colistimethate (6.3 mg/kg body weight/day for 7 days) during treatment of an abdominal abscess accompanying regional ileitis. Renal function, which had been normal, deteriorated markedly during the period of treatment with resultant acidosis, hyperkalemia, pulmonary edema, and uremia. Severe oliguria (0 to 240 ml/day) lasted 27 days during which
RANDALL RE, BRIDI GS, SETTER JG, BRACKETT NC. Recovery from Colistimethate Nephrotoxicity. Ann Intern Med. ;73:491–492. doi: 10.7326/0003-4819-73-3-491
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Published: Ann Intern Med. 1970;73(3):491-492.
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