PHILIP D. HANSTEN, PHARM, D.
To the editor: In his discussion on the mechanism of the impaired glucose tolerance that may follow use of oral contraceptives (Ann Intern Med 72:409-418, 1970), Dr. Elgee mentions the possibility that some interaction with adrenocorticoid metabolism may be involved. In support of this possibility Spangler and associates (1) have recently presented evidence that estrogen administration can markedly reduce corticoid requirements in patients with inflammatory skin disease. They propose that the estrogen-induced increase in cortisol-binding globulin (CBG) may reduce the normally rapid metabolism of hydrocortisone, with the CBG-hydrocortisone complex acting as a depot of slowly metabolized corticoid. Endogenous adrenocorticoids could
HANSTEN PD. Oral Contraceptives and Glucose Tolerance. Ann Intern Med. ;73:492. doi: 10.7326/0003-4819-73-3-492_1
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Published: Ann Intern Med. 1970;73(3):492.
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