PAUL D. WOOLF, M.D.
To the editor: The NIH Conference entitled "Adenyl Cyclase and Myocardial Contractility" (Ann Intern Med 72:561-578, 1970) was most provocative. If one extrapolates from Dr. Epstein's findings of the glucagonmedicated increase in myocardial contractility and in myocardial adenyl cyclase in cats with acute cardiac decompensation, it would seem that glucagon might be useful in the somewhat analogous situation in man—that is, cardiogenic shock. However, since the evidence indicates that this hormone activates the same adenyl cyclase system as the catecholamines, it would appear from Dr. Levey's data that the use of either T3 or T4 or one of their analogues
PAUL D. WOOLF. Glucagon and the Failing Heart. Ann Intern Med. 1970;73:493–494. doi: 10.7326/0003-4819-73-3-493
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Published: Ann Intern Med. 1970;73(3):493-494.
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