RONALD C. DECONTI, M.D.; PAUL CALABRESI, M.D.
The pyrimidine analog 6-azauridine or its oral derivative, azaribine, was used to control polycythemia vera in five patients. Amelioration of symptoms, decrease in splenomegaly, and progressive reduction of the hematocrit were uniformly achieved in 3 to 6 weeks without untoward effects. Reticulocytopenia, elevation in serum iron values, and prolongation of plasma iron disappearance time are in accord with the concept that suppression of erythropoiesis is responsible for these beneficial effects. The data suggest that this compound may be a useful agent in the management of polycythemia vera and that further studies are warranted.
DECONTI RC, CALABRESI P. Treatment of Polycythemia Vera with Azauridine and Azaribine. Ann Intern Med. ;73:575–579. doi: 10.7326/0003-4819-73-4-575
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Published: Ann Intern Med. 1970;73(4):575-579.
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