JOHN E. BENNETT, M.D., F.A.C.P.
Enthusiastic reports from Germany have aroused interest in a new antifungal agent called clotrimazole (Bay 5097). This synthetic organic chemical has inhibited the growth of some bacteria and most pathogenic fungi tested in vitro, including fungi causing ringworm and those causing systemic mycoses (1). Clinical trials with oral therapy of systemic mycoses have produced very little toxicity and very favorable therapeutic responses (2-4). No data for clinical efficacy in ringworm have been published.
Now that clinical trials in systemic mycoses will soon begin in the United States, it is worthwhile to analyze the available data critically. At this early stage
BENNETT JE. Clotrimazole: New Drug for Systemic Mycoses?. Ann Intern Med. ;73:653–654. doi: 10.7326/0003-4819-73-4-653
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Published: Ann Intern Med. 1970;73(4):653-654.
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