HOMARD R. NANKIN, M.D.; JAMES B. FIELD, M.D.; PHILIP TROEN, M.D.
To the editor: Clomiphene citrate administered to normal men for 6 days (50 mg every 6 hr) increases circulating luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (1). There was either no change or an inadequate increase in blood levels of gonadotropins when a 6-day course of clomiphene was given to men who had deficient olfactory acuity and hypogonadotrophic hypogonadism (1). Boyar (Ann Intern Med 71:1127-1131, 1969) described an anosmic man with hypogonadotrophism who failed to respond to the standard 6-day test, but the continued administration of clomiphene (50 mg/day) for an additional 26 days was associated with an increase of
NANKIN HR, FIELD JB, TROEN P. Clomiphene Therapy in Hypogonadotrophism with Defective Olfaction. Ann Intern Med. ;73:660–661. doi: 10.7326/0003-4819-73-4-660
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Published: Ann Intern Med. 1970;73(4):660-661.
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