INDER J. CHOPRA, M.D.; DAVID H. SOLOMON, M.D., F.A.C.P.
A patient had high serum long-acting thyroid stimulator (LATS) activity and only the ophthalmopathy and dermopathy of Graves' disease for several years and finally developed hyperthyroidism with no increase (actually a decrease) in serum LATS activity. This sequence generates doubt about two prevalent hypotheses: that circulating LATS is the cause of hyperthyroidism in Graves' disease and that the absence of hyperthyroidism in euthyroid Graves' disease is caused by the presence of an additional lesion, such as chronic thyroiditis, limiting the capacity of the thyroid gland to respond to LATS. Alternative hypotheses are discussed.
CHOPRA IJ, SOLOMON DH. Graves' Disease with Delayed Hyperthyroidism: Onset After Several Years of Euthyroid Ophthalmopathy, Dermopathy, and High Serum LATS. Ann Intern Med. ;73:985–990. doi: 10.7326/0003-4819-73-6-985
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Published: Ann Intern Med. 1970;73(6):985-990.
Endocrine and Metabolism, Thyroid Disorders.
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