PATRICIA A. MCINTYRE, M.D., F.A.C.P.; HENRY N. WAGNER Jr., M.D., F.A.C.P.
Spleen scanning is a valuable procedure for estimating the size, configuration, and location of splenic tissue and for detecting space-occupying lesions within the spleen. Two functions of the spleen provide the basis for spleen scanning: appropriately damaged erythrocytes are preferentially sequestered in splenic sinusoids; and the reticuloendothelial cells of the spleen, as well as those of other organs, accumulate intravenously injected colloidal particles by phagocytosis. Damaged erythrocytes or colloidal particles labeled with suitable gamma-emitting radionuclides can be used to obtain scanning images of the spleen. Although several methods are adequate for the majority of clinical problems, the colloidal preparations labeled with short-lived nuclides are preferred for routine use. Erythrocytes damaged by 1-mercuri-2-hydroxypropane provide the most precise estimate of splenic size, and the use of 51Cr-labeled erythrocytes damaged by heat is the best method for detection of accessory spleens.
PATRICIA A. MCINTYRE, HENRY N. WAGNER. Current Procedures for Scanning of the Spleen. Ann Intern Med. 1970;73:995–1001. doi: 10.7326/0003-4819-73-6-995
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Published: Ann Intern Med. 1970;73(6):995-1001.
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