PATRICIA A. MCINTYRE, M.D., F.A.C.P.; HENRY N. WAGNER Jr., M.D., F.A.C.P.
Spleen scanning is a valuable procedure for estimating the size, configuration, and location of splenic tissue and for detecting space-occupying lesions within the spleen. Two functions of the spleen provide the basis for spleen scanning: appropriately damaged erythrocytes are preferentially sequestered in splenic sinusoids; and the reticuloendothelial cells of the spleen, as well as those of other organs, accumulate intravenously injected colloidal particles by phagocytosis. Damaged erythrocytes or colloidal particles labeled with suitable gamma-emitting radionuclides can be used to obtain scanning images of the spleen. Although several methods are adequate for the majority of clinical problems, the colloidal preparations labeled with short-lived nuclides are preferred for routine use. Erythrocytes damaged by 1-mercuri-2-hydroxypropane provide the most precise estimate of splenic size, and the use of 51Cr-labeled erythrocytes damaged by heat is the best method for detection of accessory spleens.
MCINTYRE PA, WAGNER HN. Current Procedures for Scanning of the Spleen. Ann Intern Med. ;73:995–1001. doi: 10.7326/0003-4819-73-6-995
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Published: Ann Intern Med. 1970;73(6):995-1001.
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