PAUL D. SAVILLE, M.D.
Osteoporosis with fracture is an integral part of Cushing's syndrome when caused by adrenal tumor or hyperplasia. The mechanisms responsible have been unclear, but Follis (1), using standard morphological techniques, noted very few osteoblasts and no osteoclasts in osteoporotic bone from autopsy specimens. Sissons (2) described diminished osteoblasts on bone surfaces and a scarcity of osteoid borders. Both investigators concluded that impaired bone formation was an important component of the bone disease in Cushing's syndrome. Sisson's finding of retarded fracture callus formation has been confirmed experimentally in animals. Recently Jowsey and Riggs (3) studied undecalcified sections of bone labeled
SAVILLE PD. Osteoporosis and Corticoid Drugs. Ann Intern Med. ;73:1038. doi: 10.7326/0003-4819-73-6-1038_1
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Published: Ann Intern Med. 1970;73(6):1038.
Endocrine and Metabolism, Metabolic Bone Disorders.
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