M. G. CRANE, M.D., F.A.C.P.; J. J. HARRIS, M.D., F.A.C.P.; WILLIAM WINSOR III, M.D.
Twenty-two patients developed hypertension on oral contraceptive pills. Mean blood pressure of the group before, during, and after the medication was stopped was 125/76, 183/110, and 130/82 mm Hg, respectively. The average plasma renin activity, the renin substrate, and the aldosterone excretion rate were moderately elevated in the patients who were studied while on the oral contraceptives. In 8 of 10 patients studied 3 to 6 weeks after the medication had been stopped, plasma renin activity failed to have a normal increase in response to sodium restriction and standing. In 3 of 11 patients values were in the hyporesponsive range when they were tested 2 to 7 months later. Five patients were studied who developed hypertension 3 months to 5 years after starting to take a conjugated estrogen. Four became normotensive from 1 to 7 months after they stopped taking the estrogen. The two patients studied had a hyporesponsive plasma renin activity on repeat study in association with an elevated plasma renin substrate while they were taking the estrogen.
CRANE MG, HARRIS JJ, WINSOR W. Hypertension, Oral Contraceptive Agents, and Conjugated Estrogens. Ann Intern Med. 1971;74:13–21. doi: 10.7326/0003-4819-74-1-13
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Published: Ann Intern Med. 1971;74(1):13-21.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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