GEORGE R. HONIG, M.D.
To the editor: The report by Natelson and co-workers in the September issue (Ann Intern Med 73:373-378, 1970) describes an additional well-documented example of acquired factor IX deficiency in association with the nephrotic syndrome. The isolation of material having many of the properties of factor IX from the urine of this patient provides a sound basis to account for this phenomenon. It may be unwarranted, however, to conclude that factor IX deficiency existed in their other nephrotic patients based on the findings of prolongation of the partial thromboplastin time (PTT) test and the presence of factor IX activity in the
HONIG GR. Factor IX Deficiency in Nephrosis. Ann Intern Med. 1971;74:298–299. doi: 10.7326/0003-4819-74-2-298_2
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Published: Ann Intern Med. 1971;74(2):298-299.
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