NORMAN TALAL, M.D.
In Sjögren's syndrome, a connective tissue disease related to rheumatoid arthritis and systemic lupus erythematosus, the infiltration of salivary and lacrimal glands by lymphocytes and plasma cells eventually results in severe oral and ocular dryness. The earliest infiltrates are found around the small intralobular ducts. Ductal cells become hyperplastic, giving rise to the characteristic "epimyoepithelial islets." Hypergammaglobulinemia is often present, as well as antisalivary duct antibodies, rheumatoid factor, and antinuclear and other presumed autoantibodies.
Lymphoid infiltrates sometimes involve other organs such as lung, liver, skeletal muscle, and kidney. These infiltrates may appear benign or malignant, depending on their extent, invasive
TALAL N. Sjögren's Syndrome, Lymphoproliferation, and Renal Tubular Acidosis. Ann Intern Med. 1971;74:633–634. doi: 10.7326/0003-4819-74-4-633
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Published: Ann Intern Med. 1971;74(4):633-634.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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