JAMES E. DOHERTY, M.D.
Indications that digitalis serum levels might be of value in clinical practice came in studies with radioactive digitalis compounds that appeared to relate the serum level of the drug to the myocardial level. The myocardial levels of radiocarbon digitoxin first reported by Okita and associates (1-3) were not specifically related to the serum levels, probably because of the small number of patients investigated. Gonzales and Layne (4) studied tritiated digoxin serum and tissue levels in dogs (1960) and suggested that human studies might be of value. Doherty, Perkins, and Mitchell (5) reported human studies with tritiated digoxin; these indicated that
DOHERTY JE. Digitalis Serum Levels: Clinical Use. Ann Intern Med. ;74:787–789. doi: 10.7326/0003-4819-74-5-787
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Published: Ann Intern Med. 1971;74(5):787-789.
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