William Shapiro, M.D., F.A.C.P.; Kathryn Taubert, M.S.; Kenneth Narahara, M.D.
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Accurate methods for clinical measurement of plasma glycoside concentrations promise an objective guide to the use of digoxin and digitoxin. After intravenous administration peak plasma concentrations fall rapidly (digoxin, 3 to 4 hr; digitoxin, 4 to 6 hr) through concentration levels that, in the steady state, are only seen in intoxicated patients to a slow excretion slope within the "therapeutic" concentration range (less than 3 mµg/ml digoxin; less than 40 mµg/ml digitoxin). During this period there is a significant inverse correlation (P < 0.01), with changes in the time of left ventricular ejection and Q-S2. Maximum decreases in these cardiac
Shapiro W, Taubert K, Narahara K. Plasma Digitalis: A Guide to Cardiac Effects?. Ann Intern Med. ;74:822. doi: 10.7326/0003-4819-74-5-822_1
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Published: Ann Intern Med. 1971;74(5):822.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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