Philip Felig, M.D., F.A.C.P.; John Wahren, M.D.
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It is well recognized that insulin regulates blood glucose levels by diminishing hepatic glucose release as well as by increasing peripheral glucose utilization. The relative responsiveness of hepatic versus peripheral tissues to endogenous insulin has not, however, been established in man. In this study the hepatic venous catheter technique was employed to determine the influence of small increments in circulating insulin on net hepatic glucose output and total glucose utilization. Arterial and hepatic venous blood samples were obtained from 6 healthy volunteers before and during a 45-min infusion of glucose at a rate of 2 mg/kg body weight per min.
Felig P, Wahren J. Hepatic Glucose Production: Sensitivity to Endogenous Insulin Secretion in Man.. Ann Intern Med. ;74:823. doi: 10.7326/0003-4819-74-5-823_3
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Published: Ann Intern Med. 1971;74(5):823.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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