James E. Vance, M.D., F.A.C.P.
The hypothesis that multiple endocrine adenomatosis (MEA) may result from an inherited intestinal stimulus to nesidioblastosis with secondary changes in other endocrine glands was examined. Three generations of a family with MEA were compared with nonrelated islet tumor subjects.
Thus, asymptomatic MEA relatives and nonrelated islet cell tumor subjects had only islet hormone abnormalities (insulin, with glucagon or gastrin excess, or both), suggesting that nesidioblastosis may be the initial endocrine abnormality in MEA. Islet hyperplasia has also been demonstrated postgastrectomy. In additional studies we demonstrated exaggerated plasma immunoreactive insulin and glucagon-like activity responses after oral glucose in postgastrectomy subjects shown
Vance JE. Nesidioblastosis (Islet Cell Hyperplasia) in Multiple Endocrine Adenomatosis.. Ann Intern Med. 1971;74:825. doi: 10.7326/0003-4819-74-5-825_2
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Published: Ann Intern Med. 1971;74(5):825.
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