L. Baer, M.D.; H. R. Brunner, M.D.; R. Bard, M.D.; J. H. Laragh, M.D., F.A.C.P.
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The renin-angiotensin-aldosterone system may be fundamentally involved in a number of hypertensive disorders. We have studied the antihypertensive action of Clonidine (Catapres®) and its effect on these hormones in 22 hypertensive patients maintained on a constant metabolic regimen of 97 mEq or 10 mEq Na+/day. In 14 patients clonidine, 0.3 mg, orally, per day for 5 days reduced the blood pressure by a mean of 31 mm Hg systolic and 23 mm Hg diastolic. The fall in blood pressure was associated with a decrease in plasma renin activity from a mean of 1.4 ng/ml/hr to 0.75 ng/ml/hr (P < 0.02).
Baer L, Brunner HR, Bard R, Laragh JH. Suppression of Renin and Aldosterone by Clonidine.. Ann Intern Med. ;74:830. doi: 10.7326/0003-4819-74-5-830_3
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Published: Ann Intern Med. 1971;74(5):830.
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