Albert A. Carr, M.D.
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Many of the prostaglandins have vasoactive and metabolic properties. One of these cyclic fatty acids, PGA1, may be an ideal antihypertensive agent because it has predominately vasodepressor activity. A drop in arterial blood pressure is one of the main stimuli of renin release. Since prostaglandins and renin are found in the kidney and both are possibly involved in blood pressure control, it is important to determine a possible reciprocal relationship. PGA1 was given by peripheral-vein infusion to patients with essential hypertension. Unlike other vasodepressors, such as sodium nitroprusside, hydralazine, and diazoxide, which cause renin release, PGA1 given in amounts that
Carr AA. Prostaglandin (PGA1), Blood Pressure, Plasma Renin Activity.. Ann Intern Med. ;74:830. doi: 10.7326/0003-4819-74-5-830_4
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Published: Ann Intern Med. 1971;74(5):830.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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