J. Drewry, M.D.; A. C. Alfrey, M.D.; A. R. Hull, M.D.
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Three patients with adult hemolytic-uremic syndrome manifested by anuria, thrombocytopenia, red cell fragmentation, and increased fibrin split products were studied with serial renal biopsies and coagulation studies. Onset of disease occurred in the early postpartum period in two patients and during anovulatory therapy in the third. Renal biopsy showed endothelial proliferation and fibrin deposition in the lumen and walls of small and medium-sized arteries. Immunofluorescence staining showed fibrin, betal1C, and gamma globulin in vessel walls. Renal vein catheterization failed to demonstrate a gradient across the kidney for platelets, fibrinogen, or fibrin split products. Two patients were maintained on continuous intravenous
Drewry J, Alfrey AC, Hull AR. Adult Hemolytic-Uremic Syndrome.. Ann Intern Med. ;74:830–831. doi: 10.7326/0003-4819-74-5-830_5
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Published: Ann Intern Med. 1971;74(5):830-831.
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