Harriet P. Dustan, M.D., F.A.C.P.; Robert C. Tarazi, M.D.
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An ongoing study of intravascular volume-arterial pressure relationships in hypertension has shown that plasma volume measurements (RISA method) provide important diagnostic and therapeutic guides. In untreated patients with essential hypertension, renovascular hypertension, and pheochromocytoma, plasma volume was diminished and, in men, inversely related to diastolic blood pressure. In contrast, in renal parenchymal disease, plasma volume was variable and directly related to diastolic blood pressure. With first-degree aldosteronism and in patients responding specifically to diuretics, plasma volume was either expanded or inappropriately normal for diastolic blood pressure. In considerations of therapy plasma volume measurements had unexpected value. Before treatment in a
Dustan HP, Tarazi RC. The Diagnostic and Therapeutic Importance of Plasma Volume in Hypertensive Patients.. Ann Intern Med. ;74:831. doi: 10.7326/0003-4819-74-5-831_1
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Published: Ann Intern Med. 1971;74(5):831.
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