W. J. Johnson, M.D., F.A.C.P.; R. S. Goldsmith, M.D.; C. D. Arnaud, M.D.; J. Jowsey; P. J. Kelly, M.D.
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Our studies of parathyroid function in patients with end-stage renal disease maintained by hemodialysis showed that plasma parathyroid hormone concentrations (PTH) were higher in patients with severe symptomatic bone disease and correlated significantly with dialysate calcium concentration (negative) and plasma phosphate (positive). The increased sensitivity of our assay demonstrated, however, that, contrary to some reports, PTH failed to decrease to normal during 8-hr calcium infusions and increased progressively during conventional long-term hemodialysis. To determine the cause of the latter observation, calcium fluxes across the artificial kidney were measured hourly using 45Ca and differing dialysate calcium concentrations. Net calcium transfer was
Johnson WJ, Goldsmith RS, Arnaud CD, Jowsey J, Kelly PJ. Control of Secondary Hyperparathyroidism During Long-Term Hemodialysis.. Ann Intern Med. ;74:831. doi: 10.7326/0003-4819-74-5-831_2
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Published: Ann Intern Med. 1971;74(5):831.
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