Richard L. Simmons, M.D.; Allen W. Moberg, M.D.; Carl M. Kjellstrand, M.D.; John S. Najarian, M.D.
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Our previous studies have shown that an antiglobulin to cultured human lymphoblasts can prolong skin allograft survival in man across strong histocompatibility barriers. When lymphoblasts are utilized as the antigen, the product does not require absorption by either red blood cells or platelets, it does not bind to glomerular basement membranes, and it can be administered intravenously in large doses for prolonged periods. Thirty-five consecutive recipients of cadaver renal allografts received 0 to 30 mg/kg body weight of antilymphoblast globulin. In addition, standard doses of azathioprine and prednisone were administered to all patients, regardless of the antiglobulin dose. Of five
Simmons RL, Moberg AW, Kjellstrand CM, Najarian JS. Antilymphoblast Globulin in Man: Survival of Unrelated Kidney Allografts.. Ann Intern Med. ;74:833. doi: 10.7326/0003-4819-74-5-833_2
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Published: Ann Intern Med. 1971;74(5):833.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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