George W. Dennish; Donald O. Castell
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The primary function of the lower esophageal sphincter is to prevent reflux of gastric contents into the esophagus. Patients with symptomatic incompetence of this sphincter often complain of heartburn associated with smoking. This study investigated the relationship between smoking and pressure in the lower esophageal sphincter. A group of normal volunteer subjects were studied after an overnight fast. Using an infused, open-tipped recording system, pressure was monitored continuously in the lower esophageal sphincter for a 15-min basal period and for an additional 20 min after initiation of smoking two cigarettes consecutively. In each subject there was a rapid decrease in
George W. Dennish, Donald O. Castell. The Inhibitory Effect of Smoking on the Lower Esophageal Sphincter.. Ann Intern Med. 1971;74:834. doi: 10.7326/0003-4819-74-5-834_1
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Published: Ann Intern Med. 1971;74(5):834.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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