Paul H. Levine, M.D., F.A.C.P.; Ronald Herberman, M.D.; Peter McClure, M.D.; Eugene Rosenberg, M.D.; Augustine Roland, M.D.; Roman Pienta, Ph.D.; Robert Ting, Ph.D.; Brigid Leventhal, M.D.; Daniel Rubin, Ph.D.
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Since RNA viruses have been shown to cause leukemia in mice, rats, cats, and birds, intensive studies have attempted to link similar viruses with human leukemia. In the absence of a demonstrable human leukemia virus, immunological attempts to detect viral antigens have been hampered by lack of suitable controls. This study of identical twins, one with leukemia and one clinically normal, provided an excellent opportunity to use a variety of test procedures to detect an antigen in the leukemic patient, possibly tumor-specific, that would not be present in the identical twin. Four sets of identical twins, all children with acute
Levine PH, Herberman R, McClure P, Rosenberg E, Roland A, Pienta R, et al. Leukemia in Identical Twins: New Implications for Viral Oncology.. Ann Intern Med. 1971;74:837. doi: 10.7326/0003-4819-74-5-837_1
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Published: Ann Intern Med. 1971;74(5):837.
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