N. G. Brunner, M.D., (Member); T. Namba, M.D.; D. Grob, M.D., F.A.C.P.
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The effect of short, intensive courses of methylprednisolone (60 mg, intramuscularly, daily for 10 days) or corticotrophin (100 units, intravenously, daily for 10 days) was studied in 11 patients with severe generalized myasthenia gravis. A decrease in strength and response to anticholinesterase medication occurred during 30 (71%) of 42 courses of methylprednisolone and during 26 (93%) of 28 courses of corticotrophin. After cessation of each course of hormone, marked improvement in strength and response to anticholinesterase medication above the initial level occurred after 23 (55%) courses of methylprednisolone for an average of 78 days and after 16 (57%) courses of
Brunner NG, Namba T, Grob D. Use of Corticoid in the Management of Severe Generalized Myasthenia Gravis and Comparison with Corticotropin.. Ann Intern Med. ;74:838. doi: 10.7326/0003-4819-74-5-838_2
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Published: Ann Intern Med. 1971;74(5):838.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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