R. Russell Martin, M.D.
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The morphology and lysosomal enzyme content of human pulmonary alveolar macrophages from nonsmokers and from cigarette smokers were investigated. Alveolar macrophages were obtained by bronchopulmonary saline lavage from 24 healthy male volunteers, ranging in age from 18 to 46 years. The subjects included 13 nonsmokers and 11 smokers, with cigarette exposure ranging from 0.75 to 44 pack-years. A greater percentage of macrophages from smokers than from nonsmokers contained numerous discrete, autofluorescent cytoplasmic granules. Some individual macrophages from nonsmokers, however, were also filled with fluorescent material. Multinucleated giant cells were seen in washings from four smokers but were not lavaged from
Martin RR. Altered Morphology and Increased Acid Hydrolase Content of Alveolar Macrophages from Cigarette Smokers.. Ann Intern Med. ;74:840. doi: 10.7326/0003-4819-74-5-840_5
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Published: Ann Intern Med. 1971;74(5):840.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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