H. Nagaya, M.D.; H. O. Sieker, M.D., F.A.C.P.
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We reported previously 20 patients with radiological evidence of pulmonary fibrosis and coexisting antinuclear factor. In one of three patients with histological diagnosis of interstitial pulmonary fibrosis of Hamman-Rich type, IgM deposition was demonstrated in the alveolar septa. Subsequently, we studied three additional patients with tissue diagnosis of interstitial pulmonary fibrosis and serum antinuclear factor. In reviewing the histopathology of the lungs of these six patients, several characteristic changes emerged that might be of pathogenetic significance. Adjacent to fibrosing alveolar septa there were always areas of predominantly lymphocytic infiltrate with accompanying plasma cells and eosinophils. In some, fibrotic changes were
Nagaya H, Sieker HO. Pathogenetic Mechanisms of Interstitial Pulmonary Fibrosis: A Histologic and Clinical Correlation.. Ann Intern Med. ;74:840–841. doi: 10.7326/0003-4819-74-5-840_6
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Published: Ann Intern Med. 1971;74(5):840-841.
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