Ralph F. Jacox, M.D., F.A.C.P.; C. Douglas Angevine, M.D.
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Joint involvement in hemochromatosis was first recognized by Schumacher (Arthritis Rheum 7:41-50, 1964) and further delineated by Hamilton and associates (Quart J Med 37:171-182, 1968). Our experience with this disease suggests that any patient with an unusual distribution of arthritis should be investigated for abnormal iron metabolism. One patient with unusual calcific changes around the ankles and with remarkable osteoarthritic disease in the ankle joints was found to have hemochromatosis. He had a high serum iron with 100% saturation and a liver biopsy that showed a heavy deposition of iron characteristic of hemochromatosis. Radiographs of the pelvis showed nodular, bony
Jacox RF, Angevine CD. Unusual Arthritic Manifestations of Hemochromatosis.. Ann Intern Med. ;74:842. doi: 10.7326/0003-4819-74-5-842_1
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Published: Ann Intern Med. 1971;74(5):842.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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