Fritz Bach, M.D.
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The success of transplantation in man depends to some degree on antigenic disparity between the donor and the recipient tissues. Two general approaches are available for study of this problem. Lymphocyte typing uses antisera-measuring histocompatibility antigens to define the phenotype of both donor and recipient; pairing is achieved by minimizing antigenic disparity. Mixed leukocyte culture tests involve the in vitro culture of lymphocytes of the donor and the recipient to study the amount of lymphocyte response (a measure of antigenic disparity) without defining the antigens responsible for the disparity. Results using these two methods have shown that a single genetic
Bach F. Histocompatibility and Transplantation.. Ann Intern Med. ;74:843. doi: 10.7326/0003-4819-74-5-843_1
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Published: Ann Intern Med. 1971;74(5):843.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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