Franz Gross, F.A.C.P. (Hon.)
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Any discussion of the significance of the renin-angiotensin system for the pathogenesis of experimental renal hypertension has to consider that constriction of one renal artery induces hypertension, and removal of the ischemic kidney is followed by a normalization of elevated blood pressure. Both observations give evidence of the fact that a renal factor is responsible for the development and maintenance of hypertension. Renin, by reacting with the plasma substrate angiotensinogen, releases the vasopressor polypeptide angiotensin, which is rapidly inactivated. The activity of the renin-angiotensin system is inversely related to sodium balance and intravascular volume and is also affected by various
Gross F. ACP Honorary Fellowship Lecture: The Renin-Angiotensin System and Hypertension.. Ann Intern Med. ;74:843–844. doi: 10.7326/0003-4819-74-5-843_7
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Published: Ann Intern Med. 1971;74(5):843-844.
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