PHISIT CHIRAWONG, M.D.; RANJIT SINGH NANRA, M.B., M.R.A.C.P.; PRISCILLA KINCAID-SMITH, M.D., F.R.C.P., F.R.A.C.P., D.C.P.
In 46 patients with persistent glomerulonephritis, fibrin degradation products have been measured at the time of a renal biopsy. These products were present in the serum in all patients with glomerulonephritis. In 58.7% of patients the level of fibrin degradation products was elevated above the highest level detected in a normal adult. Within the group with diffuse proliferative lesions there was also a significant difference between the levels in patients with mild proliferative glomerulonephritis and those with mesangiocapillary (membranoproliferative) glomerulonephritis and fibrin and crescent formation. There was a high degree of correlation between increased levels and a blind histological grading of activity of the glomerular lesion (P < 0.005). Demonstration of fibrin by immunofluorescent methods and electron microscopy also appeared to correlate with elevated levels of fibrin degradation products. The role of the coagulation process in the pathogenesis of progressive glomerular lesions and the rationale for the use of antithrombotic and anticoagulant drugs in glomerulonephritis are discussed.
PHISIT CHIRAWONG, RANJIT SINGH NANRA, PRISCILLA KINCAID-SMITH. Fibrin Degradation Products and the Role of Coagulation in "Persistent" Glomerulonephritis. Ann Intern Med. 1971;74:853–859. doi: 10.7326/0003-4819-74-6-853
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Published: Ann Intern Med. 1971;74(6):853-859.
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