RICHARD J. DUMA, M.D., F.A.C.P.; WILLIAM I. ROSENBLUM, M.D.; READ F. MCGEHEE, M.D.; MURIEL M. JONES, M.S.; E. CLIFFORD NELSON, SC.D
Two new cases of primary amoebic meningoencephalitis and two previously reported cases are presented as the basis for a description of the clinical, pathological, epidemiological, and protozoological aspects of this infection. The patients acquired their illnesses from swimming in fresh water; the infections were culturally proved to be caused by free-living amoeboflagellates of the genus Naegleria. The infections were rapidly fatal, but in two cases the responsible pathogens were markedly inhibited in vivo (as well as in vitro) by amphotericin B; at present this drug appears to be the only promising treatment available for an otherwise fatal disease.
DUMA RJ, ROSENBLUM WI, MCGEHEE RF, JONES MM, NELSON EC. Primary Amoebic Meningoencephalitis Caused by Naegleria: Two New Cases, Response to Amphotericin B, and a Review. Ann Intern Med. 1971;74:923–931. doi: 10.7326/0003-4819-74-6-923
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Published: Ann Intern Med. 1971;74(6):923-931.
CNS Infections, Infectious Disease, Neurology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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