LOWELL S. YOUNG, M.D.; DONALD ARMSTRONG, M.D., F.A.C.P.
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To the editor: We believe that Dr. Kehl Markley's comments on the immunoprophylaxis of Pseudomonas aeruginosa infections published in the January issue of the ANNALS are too optimistic. None of the researchers cited in the references on studies of vaccine in humans with burns achieved statistically significant results while employing simultaneous, randomized controls. In his Reference 2, for instance, it is clear from the printed discussion that follows that paper that patients who received vaccine had smaller burn wound areas than unvaccinated patients at that center. Furthermore, in other published studies there is a paucity of specific data on topical
YOUNG LS, ARMSTRONG D. Immunoprophylaxis of Pseudomonas aeruginosa. Ann Intern Med. ;74:1012–1013. doi: 10.7326/0003-4819-74-6-1012_2
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Published: Ann Intern Med. 1971;74(6):1012-1013.
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