HOWARD N. WARD, M.D., F.A.C.P.; EDWARD H. REINHARD, M.D., F.A.C.P.
A chronic unexplained neutrophilic leukocytosis, observed in individuals who otherwise appear healthy, is rarely mentioned in the literature. This report is based on those patients (72) referred to the Hematology Division during the past 20 years for evaluation of a persistent leukocytosis. Only those patients (35) who satisfied the following criteria were included in the study: a total WBC count of 11,000/mm3 or more, owing predominantely to neutrophils; normal values for the other formed elements in the blood; the absence of any stimulus known to cause a leukocytosis; and documentation of the leukocytosis over a prolonged period of time. The minimum period of observation was 1½ years. Presenting symptoms included predominantely functional complaints, and physical findings were essentially normal. Since consultation two patients have died; four patients have developed an illness possibly related to the leukocytosis; none has acquired leukemia. In most patients no illness known to be responsible for the leukocytosis has appeared. Thus, a neutrophilic leukocytosis may last for years in patients who are otherwise healthy.
WARD HN, REINHARD EH. Chronic Idiopathic Leukocytosis. Ann Intern Med. ;75:193–198. doi: 10.7326/0003-4819-75-2-193
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Published: Ann Intern Med. 1971;75(2):193-198.
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