MARK E. SILVERMAN; M. D. FLAMM JR.
Prinzmetal's variant angina pectoris, as originally described, was thought to be caused by a single clinically significant major coronary artery obstruction. The recent advent of saphenous vein coronary bypass techniques makes this presumption especially important, since the clinical syndrome may identify a surgically correctable lesion. Of three cases here reported, two had single major coronary artery obstructive lesions, supporting Prinzmetal's concept of the pathologic lesion in this condition. Experience with these patients and a review of the literature suggest that the prognosis in variant angina pectoris is grave. It is concluded that angiographic study should be done early when variant angina pectoris is diagnosed and that, on the basis of present knowledge, coronary artery bypass surgery should be considered if a lesion amenable to this approach is found. Until the pathophysiology of this syndrome is clarified, however, the associated risks and the results to be expected from surgical therapy are unknown.
SILVERMAN ME, FLAMM MD. Variant Angina Pectoris: Anatomic Findings and Prognostic Implications. Ann Intern Med. ;75:339–343. doi: 10.7326/0003-4819-75-3-339
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Published: Ann Intern Med. 1971;75(3):339-343.
Cardiology, Coronary Heart Disease.
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