To the editor: Dr. Cortes's letter (Ann Intern Med 74:1014, 1971) requires some comment. The possibility of a glucagon-induced endogenous thyrocalcitonin stimulation in pancreatitis is completely unproved. This speculation is based on observations of high serum levels of glucagon in pancreatitis and on stimulation of thyrocalcitonin secretion by glucagon in animal studies. It has not yet been clearly shown that high glucagon levels in pancreatitis could stimulate endogenous secretion of thyrocalcitonin in man. In normal man glucagon probably cannot raise serum thyrocalcitonin to levels that are able to produce hypocalcemia (1, 2). Acute administration of thyrocalcitonin in doses of 200
ROLF-DIETER HESCH. Glucagon and Pancreatitis. Ann Intern Med. 1971;75:648. doi: 10.7326/0003-4819-75-4-648_1
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Published: Ann Intern Med. 1971;75(4):648.
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